Relapses Contribute Significantly to Disability Worsening in Multiple Sclerosis
By Admin | March 15, 2022
Relapses contribute to the accumulation of disability in people with multiple sclerosis (MS) and the disability occurs primarily early in the disease, according to the findings in a study published February 1 in Brain.
“While the role of clinical relapses in diagnosis is undisputed and their impact on the patient's quality of life is undeniable, the involvement of clinical relapse in long-term prognosis has been questioned," wrote lead study author Fred D. Lublin, MD, FAAN, the Saunders Family Professor of Neurology and director of The Corinne Goldsmith Dickinson Center for Multiple Sclerosis at the Icahn School of Medicine at Mount Sinai.
The aim of the study was to determine the contribution of relapses to worsening disability over the course of the disease, how early disease progression begins, and how MS therapies may delay disability accumulation.
Using data from the Novartis-Oxford MS study, the largest and most comprehensive clinical trial dataset in multiple sclerosis, the researchers analyzed the MRI results of 27,000 patients with approximately 200,000 Expanded Disability Status Scale (EDSS) transitions. The data included all multiple sclerosis phenotypes—relapsing remitting MS, secondary progressive MS, primary progressive MS, and pediatric MS—and the patients included in the study cohort had been followed for...(More)
For more info please read, Relapses Contribute Significantly to Disability Worsening in Multiple Sclerosis, by Neurology Today