Prophylactic Lumbar Drainage Following Aneurysmal Subarachnoid Hemorrhage Shows Additional Benefits
By Admin | July 05, 2023
A recently published study (NCT01258247) in JAMA Neurology showed that use of lumbar drains after aneurysmal subarachnoid hemorrhage may lessen the burden of secondary infarction and decrease the rate of unfavorable outcome relative to standard of care alone.
Otherwise known as the EARLYDRAIN trial patients were randomly assigned to receive an additional lumbar drain after aneurysm treatment (n = 144) or standard of care (n = 143), with early lumbar drainage ensuing within 72 hours after the hemorrhage. At 6 months, 32.6% (n = 47) of patients in the lumbar drain group and 44.8% (n = 64) in the standard of care group had an unfavorable neurological outcome, defined as modified Rankin Scale scores between 3 and 6 (risk ratio, 0.73; 95% CI, 0.52-0.98; P = .04).
Led by Stefan Wolf, MD, Department of Neurosurgery and Pediatric Neurosurgery, Charite Universitatsmedizin Berlin, the trial was open-label with blinded end point evaluation conducted at 19 centers across 3 countries. Patients included were at least 18 years of age and had confirmation of intracranial aneurysm by CT angiography or digital subtraction angiography. Aneurysm treatment, which included coiling or clipping, as applicable and in concordance with international guidelines and recommendations, was required to be performed within 48 hours after...(More)
For more info please read, Prophylactic Lumbar Drainage Following Aneurysmal Subarachnoid Hemorrhage Shows Additional Benefits, by Neurology Live